The man in his 60s was pronounced dead at the scene in the 1100 block of North Grand Avenue shortly after 7:30 a.m., according to the Los Angeles County Sheriff's Department.
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Deputies arrived to find the victim unresponsive and suffering from trauma, according to a news release. He was pronounced dead by responding firefighter-paramedics.
The driver of the vehicle was transported to a hospital where he was treated for unspecified injuries and is in stable condition. He was detained by authorities.
"The traffic collision appears to be an intentional act," the Sheriff's Department statement said.
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The driver was only identified as a man in his 30s.
The names of the victim and driver were not released. Their relationship to one another is unclear.
Anyone with information about the incident is to call the sheriff's Homicide Bureau at (323) 890-5500.