The California Highway Patrol reopened all the lanes hours later. Details of possible injuries were not immediately known.
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The collision, involving a semi-truck, a sedan and an overturned pickup truck, occurred shortly before 6:30 a.m. near Citrus Street, according to a California Highway Patrol incident log.
One of the vehicles was engulfed in flames after striking a pole on the center divider.
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Crews worked to contain fuel that spilled near one of the burned-out vehicles.
Eastbound traffic was backed up as far as Azusa Avenue. Shortly before 9:30 a.m., all eastbound lanes were reopened as well as the two westbound lanes.
The cause of the crash was unknown.