A police spokesperson said the incident occurred shortly before 1:30 a.m. in the 3400 block of South Flemington Drive, where the masked intruders ransacked the residence and fled.
No injuries were reported.
Descriptions of the men and what was possibly stolen were not immediately available.
Anyone with information about the home invasion is asked to call the West Covina Police Department at (626) 939-8500.
City News Service contributed to this report.