Firefighters arrived to the one-story home on Gross Avenue, near Vanowen Street, at about 11:30 p.m.
A total of 38 firefighters had the flames knocked down in just 17 minutes, according to Los Angeles firefighters.
Two people suffered burn injuries. One of them was transported to a nearby hospital in critical condition. The second victim's condition was not known.
The cause of the fire is still under investigation.