The pedestrians, who were only identified as male juveniles, were struck in the area of Triunfo Canyon Road and Saddle Mountain Drive at about 7:10 p.m., according to the Los Angeles County Sheriff's Department.
One of the victims died at the scene, while the other boy was transported to a hospital in unknown condition.
Investigators had cordoned off a crosswalk with crime scene tape, and a scooter and a set of roller blades were seen nearby the crash location.
Authorities said a driver was detained. They are investigating if street racing was a possible factor in the crash.
The area of Lindero Canyon to Twin Lakes Ridge Road was closed off due to the crash.
An investigation is ongoing.