The collision happened about 4:30 a.m. near Whittier Boulevard and left the truck on its side in the northbound lanes and a sedan overturned on the southbound side. The truck's payload of bottled water and beer was scattered across the interstate.
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Details about possible injuries were not immediately available.
Traffic was backed up for miles in both directions as crews worked to clear the scene amid multiple lane closures.
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The cause of the crash was unknown.