The collision happened about 4:30 a.m. near Whittier Boulevard and left the truck on its side in the northbound lanes and a sedan overturned on the southbound side. The truck's payload of bottled water and beer was scattered across the interstate.
Details about possible injuries were not immediately available.
Traffic was backed up for miles in both directions as crews worked to clear the scene amid multiple lane closures.
The cause of the crash was unknown.