The incident happened about 9:15 a.m. in the 11800 block of Shoemaker Avenue, according to the Los Angeles County Sheriff's Department.
Deputies responded to the residence and discovered the man and woman, who were pronounced dead at the scene. Their names were not immediately released.
"The suspect shot his wife and turned the gun on himself," the sheriff's department said in a statement.
Anyone with information about the shooting is asked to call the agency's Homicide Bureau at (323) 890-5500.