The crash was reported just after 8:15 p.m. in the area of Lomita and Avalon boulevards.
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Footage from the scene showed two heavily damaged cars that were left charred. One car had its roof completely ripped off.
Witness video also showed huge flames tearing through one of the vehicles involved.
LAFD says a person in each vehicle was killed.
Paramedics were called to the scene and found one person dead inside one of the vehicles. Paramedics set about freeing a person from inside the other vehicle, but found they had also died.
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The names of the two victims were withheld pending notification of their next of kin.
The cause of the crash was under investigation.
City News Service contributed to this report.