The incident occurred shortly 3 p.m. in the 800 block of Bay View Avenue, prompting a massive response from Los Angeles police.
One woman was pronounced dead at the scene, the LAPD said. A man with multiple gunshot wounds was transported to the hospital and pronounced dead there.
A woman in her 20s was wounded and transported herself to the hospital. A woman in her 70s had a graze wound and declined medical transport.
The deceased individual was not immediately identified.
No description of the shooter was available. Investigators said a black Honda was seen fleeing the scene.
Police believe the shooting was gang-related.