South Los Angeles CHP officers responded to a call of a hit-and-run crash on E. Willowbrook Avenue, south of 124th Street, at about 10 p.m. Thursday night.
The victim struck was rushed to a nearby hospital, where she later died, authorities said.
Police know of at least one vehicle involved, but they may also be looking for a second car, which would make the deadly crash a hit-and-run investigation.
No further information was released as authorities continued their investigation.