The crash happened at about 10 p.m. in the 22000 block of Dumetz Road, near Topanga Canyon Boulevard.
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Two of the women were trapped in the wreckage, and were extricated by Los Angeles firefighters. A third victim was found outside of the vehicle, on the sidewalk, when emergency crews arrived on scene, said the L.A. Fire Department.
Two of the victims were taken to a regional trauma center in critical condition. A third died at the scene.
None of the victims have been identified, but officials say they were young in age.
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The roadway was partially closed while the investigation was underway.
No further details were immediately known. The cause of the crash is under investigation.