The crash happened at about 10 p.m. in the 22000 block of Dumetz Road, near Topanga Canyon Boulevard.
Two of the women were trapped in the wreckage, and were extricated by Los Angeles firefighters. A third victim was found outside of the vehicle, on the sidewalk, when emergency crews arrived on scene, said the L.A. Fire Department.
Two of the victims were taken to a regional trauma center in critical condition. A third died at the scene.
None of the victims have been identified, but officials say they were young in age.
The roadway was partially closed while the investigation was underway.
No further details were immediately known. The cause of the crash is under investigation.