The San Bernardino County Sheriff's Department identified the teacher as 38-year-old Tracy Vanderhulst.
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Detectives say the alleged victim is a 16-year-old male student at the school.
In 2017, Yucaipa High School tweeted out a picture of Vanderhulst stating she won the school's teacher of the year award.
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Bail has been set at $30,000.
Investigators believe there may be additional victims.