The crash happened just before 2 a.m. Sunday near Overland Avenue, according to the California Highway Patrol.
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Cristina Weidya, 51, was driving eastbound on westbound lanes when she crashed head-on into another vehicle with three people inside.
The 19-year-old driver of that car died at the scene. She has not been identified. The 13-year-old and 15-year-old passengers in that car were seriously injured.
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Weidya also sustained major injuries and was later arrested. It's not clear if drugs or alcohol were a factor in the crash, which shut down the freeway for several hours.