The incident occurred shortly after 2:30 a.m. in the 11200 block of Thienes Avenue, according to the Los Angeles County Sheriff's Department.
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Deputies arrived at the scene to find a man in his late 40s or 50s suffering from a stab wound to his upper torso, investigators said. Firefighter-paramedics pronounced him dead at the scene.
"Investigators learned that the decedent along with possibly two other suspects were attempting to steal vehicle parts from a vehicle parked in the driveway of the location," the Sheriff's Department said in a news release.
The stabbing occurred after the resident exited the front door of the home and was confronted by the suspects, authorities said. According to investigators, the resident went outside with a kitchen knife. Specific details of what happened next have not been provided, but authorities say there was an altercation between the resident and the individuals in his driveway.
The homeowner was detained for questioning. He is considered a person of interest at the moment, and has not been arrested, according to sheriff's department Lt. Michael Gomez.
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The other suspects were last seen fleeing eastbound on Thienes Avenue in a compact vehicle.
Anyone with information about the incident is asked to call the sheriff's Homicide Bureau at (323) 890-5500. Anonymous calls can be made to Crime Stoppers at (800) 222-8477.