Bialik, who is best known for her role in "The Big Bang Theory," made the announcement on Instagram Sunday and said the virus is "no joke."
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She said exhaustion has been the most difficult symptom.
"Why did I ever go out? Why did I think everything was fine ever?" Bialik said.
Bialik has asthma, making her immunocompromised.
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A spokesperson for the game show host said that she's fully vaccinated.
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Bialik is hoping the virus passes quickly and that her body knows what to do to heal.