Both tickets matched five numbers and are worth $650,579, according to the California Lottery.
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One ticket was bought at a Lancaster liquor store on E. Avenue K, and the other ticket was purchased at a Lincoln Heights liquor store on Pasadena Avenue.
The drawing was the 30th since the last time a ticket with all six numbers was sold.
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The odds of matching all five numbers and the Mega number is 1 in 302,575,350, according to the California Lottery. The overall chance of winning a prize is 1 in 24.
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The massive jackpot now gets even bigger. The drawing for the new $1.25 billion jackpot will be on Friday.
City News Service contributed to this report.