The incident happened the morning of Nov. 5 near Main and E. 17th streets, just off the 10 Freeway, according to officials.
According to the Los Angeles Police Department, the pursuit started when officers saw a gun being thrown out of a green minivan near Central Avenue and the 10 Freeway.
Dashboard camera video, which was posted to LAPD's YouTube page, showed police following the green minivan, which they said had paper plates. The driver pulled into a gas station and then sped onto the 10 Freeway.
2 dead after minivan involved in police chase crashes into Metro bus in DTLA
Shortly after, the minivan exited the freeway, crashing right into the bus. The impact so powerful, it knocked over a passenger who was standing inside the bus, surveillance video showed.
The driver, identified as Albert Diaz, and the front passenger of the van were taken to the hospital with non-life threatening injuries. Diaz was later taken into custody.
The two rear passengers, who appeared to not have been wearing seatbelts, both died.