Firefighter-paramedics responded about noon to a report of a possible overdose of an unknown substance at Sunnymead Middle School on Eucalyptus Avenue, a spokesperson for Cal Fire Riverside said.
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A spokesperson for the Moreno Valley School District described the matter as a "medical incident."
Four students were evaluated at the scene, according to Cal Fire. Three of them were transported to a hospital in unknown condition. The fourth student was released to parents.
Due to the presence of emergency vehicles on campus, parents were made aware of the incident via a mass notification, the school district spokesperson said.
Later Wednesday, officials told Eyewitness News it appears the students ingested an edible product containing marijuana and experienced a range of symptoms including vomiting and pale complexion.
Officials are investigating where the products came from. No arrests have been made.
There have been other overdose incidents at other Southern California schools recently.
At least 10 students treated for possible cannabis overdose at Van Nuys Middle School, officials say
At least 10 students treated for possible cannabis overdose at Van Nuys Middle School, officials say
Last week, at least 10 Los Angeles students were treated for what officials described as a medical emergency after the students possibly ingested cannabis edibles.
Those students, between 12 and 15 years old, were in mild to moderate distress at Van Nuys Middle School around 10:30 a.m. Thursday, according to the Los Angeles Fire Department. Seven of them were taken to pediatric medical centers.
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The Associated Press contributed to this report.