The robbery was reported shortly after 1:30 a.m. Wednesday in the 1800 block of Huntington Drive, according to the Los Angeles County Sheriff's Department.
The suspect made off with about $300 in cash and remained at large, a sheriff's spokesperson told ABC7.
No injuries were reported.
The robber was described only as wearing a black mask and black gloves, authorities said.
At least 6 more 7-Eleven stores robbed overnight across Los Angeles County
It was unclear whether the robbery was linked to multiple recent robberies at 7-Eleven stores in Los Angeles and Orange counties.