Firefighters responded to the blaze burning next to the freeway near La Tuna Canyon Road around 4:12 p.m., according to the Los Angeles Fire Department. Two lanes were shut down.
Crews managed to get the upper hand Friday night and stopped the fire at 43 acres, while containment increased to 40%, fire officials said.
The Sunland Boulevard on-ramp, the La Tuna Canyon Road off-ramp, and the #3 and #4 lanes of the eastbound 210 freeway will all be closed for the next 24 hours, LAFD said.
Motorists are encouraged to find alternate routes.
At the height of the fire, a large plume of smoke was visible from the La Tuna Canyon area, and flames were burning very close to eastbound lanes.
L.A. city and county fire crews were coordinating efforts to battle the blaze on the ground and in the air.
It's unclear what sparked the blaze. No injuries were reported.
Fire crews will remain on scene overnight to increase containment and cool the area involved in the brush fire.
Elsewhere in the region, crews are battling the Fork Fire in the Angeles National Forest. That fire above Glendora has grown to about 250 acres.