The pets were taken following complaints about inhumane living conditions.
Massive animal rescue in Lake Hughes: Here's what we know
On Friday, a search warrant for violation of animal welfare laws was served on 266th Street West, according to the County of Los Angeles Department of Animal Care and Control (DACC).
More than 70 animal care and control staff responded to the rescue operation.
ORIGINAL REPORT: 300 dogs, cats being rescued after search warrant served at Lake Hughes property
300 dogs, cats being rescued after search warrant served at Lake Hughes property
In total, 316 animals were taken from the home, including 250 dogs and 66 cats. The pets were in the custody of Chris D'Anda of Rock N Pawz Animal Rescue.
With shelters now overflowing, some prospective pet owners say the moment is right to help.
"If you have the space and might have the time, why not?" said Mateo Yamato, who is looking to adopt. "There's really no better time... The amount of dogs and cats and other animals that are coming in right now, it's sad. If you can prevent some of those deaths from happening, it's a great thing."
All seven county shelters opened for an extra day on Sunday, encouraging adoptions to make room for the new pets.
The massive seizure followed numerous tips claiming the animals were living in inhumane conditions. So far, no charges have been filed.
Some of the animals were sent to veterinary hospitals for care, while others were sent to the county's animal care centers and partner facilities.
The county said it couldn't share details about the current conditions of the animals seized due to the investigation that is ongoing, only saying that they were living in deplorable conditions, and that some of the animals required immediate care.
L.A.-based organization Paws for Life K9 Rescue is flying nearly 100 of the dogs to Chicago for adoption on Tuesday to help alleviate overcrowding at local shelters.
The county says it is trying to facilitate the process to adopt or foster as this case moves forward, so they can continue caring for the animals seized.
"All adoption fees are waived, and what that covers is spay/neuter, the adoption fee, microchip, and the only thing it doesn't cover is licensing and trust," said Christopher Valles, the animal patrol manager at DACC.
D'Anda of Rock N Pawz Animal Rescue told Eyewitness News she rescues animals, and the dogs and cats at her home were not mistreated.
In posts on Instagram, Rock N Pawz Animal Rescue claimed it was receiving serious threats and that some dogs were injured by DACC during the raid.
"My animals were not a threat to anybody," she said. "They were healthy. They were cared for."
SEE ALSO: Rescue targeted in Lake Hughes seizure of over 300 pets pushes back on claims from LA officials
Rescue targeted in Lake Hughes raid denies claims about pets' health
But nearby residents said there's been a foul odor coming from the property for a couple of years.
"It's been smelly, and whenever they go out to feed, I'm assuming that's what they're doing, it sounds like the world's biggest dog fight," Lake Hughes resident Dave Canfield said.
Another neighbor, Susan Zahanter, said the odor and lack of infrastructure had long been a problem.
"The odor is horrific. There's no septic system on the property for the kennel. They have gone without dumpsters for months on end," she said.
The department said it has received complaints for years. It wasn't until recently that the department was able to obtain a warrant to go in and remove the animals.
Officials say it is the largest number of dogs and cats the DACC has ever seized, and it may be the largest case ever in the country. They said a charity chartered a plane to fly about 27 dogs and several cats to agencies in the Pacific Northwest.
How can I help the animals?
DACC is requesting the public's help to support the rescue and rehabilitation of the animals -- either through adoption or donations to the Los Angeles County Animal Care Foundation.
The Downey Animal Care Center shared that it took in about 100 animals from the Lake Hughes operation. Now, the shelter is overwhelmed.
So far, the Downey location says there were about six or seven adoptions over the weekend, and about 200 county-wide.