The teenagers, all from Long Beach, were in a suspected stolen Kia that was being tracked by a police helicopter before it crashed with a semi-truck near the Anaheim Street exit.
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The crash was reported just before 10:30 p.m. and led to the closure of the northbound 710 for a few hours.
Footage from the scene showed the Kia engulfed in flames. Officers rushed toward the burning car and pulled the people inside to safety.
The 15-year-old driver of the Kia was taken to a hospital where he was pronounced dead, according to the California Highway Patrol.
Three passengers in the Kia - a 13-year-old girl, a 14-year-old boy and a 15-year-old girl - were hospitalized with moderate injuries.
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The condition of the 22-year-old driver of the semi-truck was not disclosed, but he apparently was not seriously injured.
A CHP news release stated that the 15-year-old driver apparently tried to get off the freeway and cut in front of the semi-truck, causing the two vehicles to collide.