According to the Los Angeles Police Department, multiple masked and gloved suspects entered The Pharmacy Depot on Pico Boulevard around 3 a.m.
Surveillance video shows one of the suspects carrying what appears to be a power tool, jumping the counter and rushing toward the medicine shelves.
It is unclear what was taken.
The owner told Eyewitness News this is the fourth time the pharmacy has been burglarized.
This comes after a rash of pharmacy burglaries in the San Fernando Valley, but LAPD's Wilshire Division said they have not experienced pharmacy burglaries like they have.
No arrests have been made in connection with the burglary.