The mayor held a news conference at Children's Hospital Los Angeles on Tuesday expressing his support for Proposition 4.
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Supporters say the $1.5 billion initiative would help ensure top medical care for the city's youngest and most vulnerable.
Opponents say the proposition is nothing more than taxpayer dollars funding private institutions.
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Garcetti says Proposition 4 is the right thing to do.
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"Children's lives are in danger in California, but Prop. 4 can help save those lives. We know this is one of the best investments we can make. Whenever we invest in the healthcare of our youngest, we all prosper - not just because it's the right thing to do, but we know how expensive it is later in life," Garcetti said.
Voters will decide on Prop. 4 when they go to the polls on Nov. 6.
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