Drivers were urged to bring tire chains when traveling in the San Bernardino Mountains.
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Caltrans crews worked throughout the night and into the morning hours to clear a light dusting of snow from the 15 and 138 freeways in the Cajon Pass.
A winter weather advisory is scheduled to expire at 10 a.m. Thursday for areas of the Inland Empire above 2,500 feet.
In the mountains, a winter storm warning remained in effect until 10 p.m. , with additional snow accumulations of 5 to 9 inches above 3,500 feet, as well as localized amounts up to 16 inches, expected. Dense fog is also in the forecast.
Storm timeline: How long will rain continue across Southern California?
Rain, snow to continue across SoCal Thursday
"Be prepared for significant reductions in visibility at times,'' the National Weather Service warned.
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Heavy snow and gusty winds may also result in some downed tree limbs and power outages, the weather service said.
City News Service contributed to this report.