The fatal collision happened Jan. 9 near Main Street and 11th Place, according to police.
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Surveillance video shared by a local business shows the moments leading up to, and immediately after, the crash. Investigators believe a driver in a silver Mercedes may have sped through a red light as it was traveling on Main and hit a silver SUV that was traveling on 111th.
The boys' mother was driving the SUV. She and the front passenger, a 16-year-old, were injured. Her 13-year-old son Chris Amaya-Pineda died at the hospital last week.
On Monday, family members confirmed that his 2-year-old brother, Damian, also succumbed to his injuries.
Driver sought in South LA hit-and-run crash that left 4 injured, including 2 teenagers and toddler
A candlelight vigil was held Monday night at the scene of the crash to support the grieving parents.
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"I was dropping them off at Grandma's house and I didn't see this coming," said their mother, Deborah Amaya. "I didn't just lose one. I lost two of my sons."
A GoFundMe page has been set up to help cover funeral and medical expenses.
The suspect who hit the victims has yet to be identified.