The storm is forecast to bring heavy snow of 4 to 8 inches at snow levels as low as 2,500 to 3,000 feet, according to the National Weather Service.
The California Highway Patrol was conducting escorts on Interstate 5 Monday morning, pacing drivers as light snow fell. The escorts ended just after 6:30 a.m., the CHP announced in a tweet.
The snow could significantly impact travel along the 5 Freeway, particularly over the Grapevine, the NWS said.
Travel on mountain roads including Interstate 5, 2 and 14 could become difficult or impossible, just as last week's storm proved.
A major snowstorm caused dangerous driving conditions through the Grapevine, shutting down the 5 Freeway for more than 36 hours beginning on Christmas.
Officials are warning drivers to take precautions and expect hazardous road conditions.