The campaign is called "Heads Together" and with it, they hope that prejudice and fear no longer stand in the way of people getting the help they need.
Prince William, Duchess Kate and Prince Harry all appear in the PSA, and it is the biggest single project they've taken on in unison.
The Royal Foundation will work with a number of mental health charities for the project. "Heads Together" will also headline the London marathon in 2017.
This is a cause near and dear to the royal family's hearts. To follow along and show your support on social media, use hashtag #HeadsTogether.