The incident happened early Wednesday morning on North Sunnyslope Avenue near Riverside Drive.
Residents in the area said they were sound asleep when they heard a loud crash and briefly lost power.
"It felt kind of like an earthquake," one man, whose car was missed by just a few feet, told Eyewitness News. "It was a massive bang."
It's unclear exactly how many cars were damaged. No injuries were reported.
The Los Angeles Department of Water and Power and tree-cutting crews responded to the scene to asses the damage and clean up the mess.
The tree toppled over on a night where there were winds across Southern California, but the National Weather Service doesn't believe this incident was wind-related.