The actor opened Thursday night's episode as a kidnapper who tied Kimmel to a chair with duct tape and gagged him with his own tie.
Kimmel has joked for years at the end of his show that he ran out of time to bring Damon on as a guest. On Thursday's episode, however, Kimmel was the silent one, watching from the back of the stage as Damon took over hosting duties.
Damon brought on one big-name guest after another, tormenting Kimmel. Guests included Robin Williams, Ben Affleck, Sheryl Crow, Nicole Kidman, Gary Oldman, Amy Adams, Reese Witherspoon and Demi Moore.
"I've been waiting for this moment for a long, long time," Damon said. "This is like when I lost my virginity, except this is going to last way longer than one second."
Damon's guest hosting stint comes at a key time for Kimmel. Earlier this month, ABC moved the show to 11:35 p.m. ET and PT after a decade of airing it a half hour later, putting him in direct competition with Jay Leno and David Letterman.
The sweetest revenge of all came near the end of the show, when Damon promised to ungag Kimmel in the show's final minutes.
"Wait," he said. "I'm sorry. We're out of time."