Los Angeles firefighters were assisting California Department of Fish and Wildlife and Los Angeles Animal Control in the rescue effort in the 2700 block of Glendower Avenue, located in the hillsides near Griffith Park.
Fish and wildlife officials shot bean bag rounds and tennis balls and even poked it with a stick, but the puma refused to move. After a while, crews gave up for the night.
"We're going to let him settle. We're going to let everything calm down. We're going to be really still and give him time to get out of there," said Janice Mackey with California Department of Fish and Wildlife.
Homeowners told Eyewitness News that the cougar was found by crews working on the home.
"One worker came sprinting to through our house, white-faced, shouting, 'There's a mountain lion under your house!" Paula Archinaco said.
"I thought he was punking me, frankly," Jason Archinaco said.
P-22 is known to live in Griffith Park. He is believed to be the first mountain lion to leave the Santa Monica Mountains and cross over the 405 Freeway.
P-22 made headlines last year after it was exposed to rat poison. He was captured, treated and returned to Griffith Park.