The collision was reported shortly after 3 a.m. near Del Amo Boulevard, according to a California Highway Patrol incident log.
At least one person was killed in the crash. The identity of that individual was not immediately released.
Northbound traffic was diverted off the 710 at the Del Amo Boulevard exit. Meanwhile, traffic was significantly backed up on that side of the freeway for hours as the morning commute got underway.
All northbound lanes were reopened just before 6 a.m.
The cause of the collision is under investigation.