The closure comes after recent heavy rains left Southern California hillsides oversaturated, leading to landslides and mudflows throughout the region.
"With recent rains and even rains last winter we understand it's just percolating down from the hills above us and its causing asphalt to surge in ways we have never seen before," said Rev. Dan Burchett, executive director of the chapel.
Several homes were damaged last year in nearby parts of Rancho Palos Verdes.
Rancho Palos Verdes homeowners express concern as land movement continues
"Effective immediately, we are extremely devastated to announce the closure of Wayfarers Chapel and its surrounding property due to the accelerated land movement in our local area," the chapel announced.
"For those who have confirmed reservations at Wayfarers Chapel, please know refunds will be issued, and our Weddings and Events Office will be in contact with you soon."
There was no word on when it might reopen.
Wayfarers Chapel was designed by Lloyd Wright, son of famed architect Frank Lloyd Wright, and opened in 1951 on a scenic hillside overlooking the Pacific Ocean. It is known as a popular site for weddings and a filming location.
Two months ago, it was added to the register of National Historic Landmarks, with federal officials describing it as "an exceptional example of modern organic ecclesiastical architecture."
Wayfarers Chapel nominated as National Historic Landmark
Wayfarers Chapel, designed by Frank Loyd Wright Jr., receives National Historic Landmark nomination
"The decision to close Wayfarers Chapel for public safety is the right one, but it is still devastating news and another reminder of the seriousness of this land movement," County Supervisor Janice Hahn said. "Wayfarers Chapel is one of the more beautiful chapels in the country if not the world and we all have treasured memories there."
The chapel plans to start a GoFundMe page to help pay for structural renovations but in the meantime, there is a donation link on its main website.
Last summer, at least two homes in Rancho Palos Verdes and another dozen in nearby Rolling Hills Estates were red-tagged because of land movement. Residents said underground waterline breaks contributed to the problem, on top of the heavy rainfall from last winter.