Deputies responded to the campus at 27501 Mustang Run shortly after 1 p.m., according to the Orange County Sheriff's Department.
"The school is currently on shelter in place while deputies ensure the campus is safe," the agency said on Twitter. "At this time, it appears to be an isolated incident and one person has been detained."
One person, a male teen, was stabbed with a knife and taken to the hospital with non-life-threatening injuries, according to officials. Another male juvenile was taken into police custody.
"I know that two girlfriends were fighting, and the boyfriends apparently jumped in," the grandmother of two students at the school told Eyewitness News. "One of them had a butterfly knife, and on the video, it looked like he had been stabbed four or five times."
Authorities have not corroborated those exact details.
The school lockdown was lifted shortly after 3:30 p.m., according to officials.
No further details were immediately known. The investigation is ongoing.