The Lakers' starting center rolled his ankle after trying to challenge a shot from behind. He underwent X-rays, which were negative, but the team said Lopez will undergo an MRI on Tuesday.
Lopez left Staples Center wearing a walking boot and using crutches. He told ESPN's Ramona Shelburne that he will not join the Lakers on their upcoming road trip, which has stops Wednesday at Houston and Friday at Golden State.
Lopez has required surgery on his right foot before. In 2014, while with the Brooklyn Nets, he underwent surgery to repair a fractured fifth metatarsal of his right foot.
Lopez also had a second procedure, a first metatarsal osteotomy, that repositioned another bone in his foot to "unload and protect the injured area."
In 2011, Lopez fractured the same fifth metatarsal, which required a screw to be replaced in it.
Lopez went into Monday night averaging 13 points and 4.4 rebounds in 22.9 minutes per game this season.
Lopez helped off court after spraining ankle
Late in the second quarter, Brook Lopez sprains his ankle making a defensive play on Kevin Durant. Lopez is assisted off the court by his teammates and would not return to the game.