John Isner, the highest-seeded U.S. player in the men's draw at No. 19, lost in five sets to Mischa Zverev at the Australian Open -- one of several American men to stumble Wednesday in Round 2.
Roger Federer's streak of nine consecutive quarterfinals at the French Open ended Sunday with a 6-7 (5), 7-6 (3), 6-2, 4-6, 6-3 fourth-round loss to 18th-seeded Ernests Gulbis of Latvia.
For the second time in his unparalleled French Open career, Rafael Nadal owns a 31-match winning streak at the clay-court Grand Slam tournament.
