Nadine Menendez surrendered to federal authorities Friday afternoon and is in the custody of the Bureau of Prisons at the Federal Correctional Institution Tallahassee.
U.S. Sen. Bob Menendez announced his wife is battling breast cancer, and she will require a mastectomy as the two face separate corruption trials.
Menendez has pleaded not guilty to 16 federal charges including bribery, fraud, acting as a foreign agent and obstruction.
Menendez may attempt to lay the blame for the alleged conspiracy on his wife, Nadine, whose trial was delayed due to a medical issue.
Sen. Menendez, who has pleaded not guilty to all prior counts, is now accused of making positive comments about Qatar in exchange for items of value.
Menendez, who is charged with conspiring to act as an agent of Egypt and other offenses, is scheduled to stand trial in May and sought a two-month delay.