Founder Helen Harris, who is legally blind herself, says the school is a crucial resource for those with degenerative eye disease.
Harris says public funding has dried up and donations have plunged more than 50 percent.
"And that affects us in two ways, with our medical research for RP, and for day-to-day school that we have for the blind. It's going to close," said Harris.
The school is launching a last-ditch fundraising campaign this weekend.