LAPD officers said the three victims, including 25-year-old David Garcia, were shot as they sat inside a car outside Garcia's family home.
At least two armed men walked up to the vehicle, fired several rounds and then fled on foot. One victim was killed, two others, including Garcia, suffered multiple gunshot wounds to the torso and legs. They were transported to area hospitals.
Police said they're not sure why the victims were targeted and a motive was undetermined.
"It's not a known gang location. They didn't have any telltale signs as far as dress to lead anybody to believe they were gang members," said LAPD Sgt. Scott Stevens.
Garcia's family said he was listed in critical condition, and neighbors said they're praying for both surviving victims as they try and make sense of what happened on this quiet street.
"I really was surprised that this happened. Nothing ever happened like this in this neighborhood. I've been living here since 1975," said neighbor Carolyn O'Neal.
Garcia's uncle, Hector Ruiz, said he's fearful that the shooters may kill again and remains hopeful that the men detained are in fact the gunmen. Residents also said it will be hard to feel safe until the shooting case is closed.
"It makes me feel scared to even go to the store because I don't know what the motive of the situation was," said neighbor Velissa Johnson.
It remained unclear if the victims knew the shooters.
If you have any information regarding this crime, you're urged to contact the LAPD at (877) LAPD-24-7 (527-3247).