Witherspoon said she sometimes sits in her car crying because she can't go out in public as much as she'd like.
However, the actress also told the magazine she wouldn't trade in her life for anything, as she truly values the vast life experience she's gained in her acting career.
Witherspoon also said she feels blessed that her friends help provide some privacy.
Her latest film, "Water for Elephants," is scheduled to be released April 22.
Witherspoon plays a scrappy circus star willing to do whatever it takes to survive. The Depression-era drama is based on the best-selling novel.
"Twilight" star Robert Pattinson co-stars as her love interest in the film.
The Associated Press contributed to this report.