The car-to-car shooting killed aspiring rapper Kenneth "Kenny Clutch" Cherry. He was shot by a gunman riding in a black Range Rover. The gunman was believed to have fired from the passenger seat into Cherry's Maserati.
Cherry's family say he did not live a violent lifestyle.
"He wasn't too much into violence, he's got three kids," said Cherry's cousin Dudy Irvin. "He just had a new baby girl that we just celebrated, not even a month or two ago."
Cherry's Maserati drove through the intersection of Las Vegas and Flamingo boulevards after he was shot and hit a taxicab.
The taxi driver was identified as Michael Boldon. He and his passenger both died after the cab caught fire.
"It's life-changing, life-changing, that's what it is," said Tehran Boldon, Michael's brother. "You lose a brother, you lose a son, it's life-changing."
Las Vegas Metro Police have launched a multi-state search for the Range Rover that fled the scene. The vehicle is described as black with dark tinted windows and dark rims, bearing out-of-state dealer plates.
Police are trying to calm nerves. Thursday's shooting marks the fifth violent incident on the Vegas Strip since December.
"You have to remember 42 million people come to Las Vegas ever single year," said Las Vegas Police Officer Marcus Martin. "That's a lot of people, and the vast majority of them are untouched by an event such as this."