The incident occurred at the Deluxe Motel located in the 900 block of West Holt Avenue shortly before 10 p.m. Saturday. Sheriff's officials say members of a gang task force were driving through the motel's parking lot when they confronted the woman. Officials say the woman flashed her firearm, and that's when officers fired.
It's unknown if the woman tried to fire back. No officers were hurt.
The woman was pronounced dead at the scene.
Police had been beefing up patrols in the same area, west of downtown, following an escalation of violence, including the killings of four young men within just six days.
The incident remains under investigation. If you have any information about this incident, you're urged to contact the Los Angeles County Sheriff's Department's Homicide Bureau at (323) 890-5500.