A judge approved the couple's breakup on Tuesday after nearly 14 years of marriage. Their divorce settlement details are confidential.
Cox and Arquette filed for divorce in 2011 and the couple legally separated Dec. 31, 2011. The two met while filming "Scream."
When they announced their split in October 2010, the couple said they were committed to raising their daughter, Coco together and remained best friends.
Cox gained widespread fame for her role on the series "Friends." Arquette was an executive producer of her recent series, "Cougar Town," and has appeared in numerous films.
The Associated Press contributed to this report.