Massive flames and thick smoke were seen shortly before 3 a.m. at Basic Black Studio Rentals along the 1100 block of South La Brea Avenue near Edgewood Place.
Firefighters say the blaze started outside the store. Furniture on display along the outer patio suffered the most damage.
The store rents out high-priced and unique furniture pieces for Hollywood movie sets. It has been in business for two generations.
Arson investigators and about 30 firefighters were on scene. It took crews about 20 minutes to knock down the flames.
A two-story apartment building directly behind the store was threatened for a short time but did not sustain any damage. No one was hurt.
Authorities say the business is not a total loss, but the store did suffer a considerable amount of damage. The cause of the fire remains under investigation.