Nearly 150 firefighters responded to the three-story home on the 5200 block of Calatrana Drive shortly before 8 p.m. About 30 minutes later, the blaze was deemed a "major emergency," according to Los Angeles Fire Department spokeswoman Katherine Main.
Firefighters got out of the home due to the potential for collapse, said Main.
A helicopter was brought in to drop water on the blaze. Crews managed to knock down the fire by 9:30 p.m. The house appears to be a total loss.
Fortunately, the flames did not spread to nearby brush, and no injuries were reported.
The cause of the fire remains under investigation.
City News Service contributed to this report.