At first, the women may have been giving proper care, but investigators say that changed.
The two women and the man are believed to be friends, but investigators says the treatment they gave the man could lead to life prison terms.
Henretta Little, 28, and 25-year-old LaPrinces Jones are cousins also facing kidnapping, assault, unlawful imprisonment, and abuse of a vulnerable adult charges.
That vulnerable adult is a 22-year-old Saginaw man that police say was diagnosed with a mental impairment.
"They were providing care for him because of his incapacitation, and at some point they began to physically abuse him, up in to the point where he was eventually not free to live and held against his will at this home," said Saginaw Police Detective Joe Dutoi.
A home on Jefferson Street is where Dutoi says the abuse began in November and ended last week when the man escaped.
"He went up through the attic and jumped out an attic window out onto a deck, which caused some of his injuries," Dutoi said.
The man jumped from the window and ran to nearby St. Mary's of Michigan, where medical personnel called police.
Investigators are looking at the victim's Social Security checks as one possible motive for the alleged crimes.
"It was amazing, the story I heard, and I knew it was completely false," said Jackie Banks, who knows the man. "It wasn't true."
Banks knows the man, who is not being identified, and says he visited him at the home. He says Jones and Little did not abuse the man.
"I never saw bruises on (him)," he said. "(He) never told me that he was being beat on, or kidnapped or held against his will.
"We have some pretty good evidence that says different," Dutoi said.
Saginaw police say the man is now being cared for by family members.