"This complex and fluid investigation has been taking place over the last 30 days," the Police Department said in a news release.
The names of the suspects were not immediately released because detectives were continuing to investigate and attempting to track down others involved in the drug-trafficking operation, the statement said.
Investigators learned that "drug pick-ups" were happening throughout Southern California, including Orange, Riverside and San Bernardino counties, according to authorities.
"It was also determined that the drug-trafficking organization was shipping large amounts of drugs across state lines and into the state of New York," the news release said. Detectives surveilled "multiple identified locations and adapting to rapidly evolving situations, culminating in the arrest of two suspects."
More than $60M in meth, cocaine seized in one of LA County's biggest drug busts
One man was arrested in Compton, allegedly in possession of two kilograms of cocaine, and a charge was being sought alleging possession with intent to sell.
The other man was arrested in San Bernardino County with the assistance of the California Highway Patrol, and was allegedly in possession of 138 kilograms of cocaine and heroin, 12 pounds of methamphetamine and more than 1,000 fentanyl pills, Carey said. A charge of transportation and possession with intent to sell was being sought against him.
The two suspects were arrested between June 7 and June 9.