Bill Cosby's spokesman says the comedian's daughter, Ensa Cosby, has died in Massachusetts.
She was 44 years old.
According to a family statement, Ensa Cosby "recently died from renal disease."
Spokesman Andrew Wyatt says: "Please keep the Cosby family in your prayers and give them peace at this time."
Bill Cosby has a court hearing scheduled this coming Monday and Tuesday ahead of his re-trial on sex assault charges in Montgomery County, Pa.
Cosby lost another child in 1997 when his son Ennis was shot to death during a robbery attempt in Los Angeles.
Ensa Cosby appeared on one episode of "The Cosby Show," which ran from 1984-1992.